Ignite Your Senses,
Rediscover Smell
and Taste
CYR-064 Phase 2 FLAVOR Trial Results to be Featured at the
72nd Annual Meeting of the American Rhinologic Society
The first pharmaceutical therapy
for taste and smell loss.
At Cyrano Therapeutics, we’re dedicated to developing therapies for people dealing with long-term loss of smell and taste. Prior to the COVID-19 pandemic, this condition affected over 15 million people in the U.S., with about 4 million cases resulting from flu viruses. Since COVID-19, however, the prevalence has increased over tenfold, with thousands of new cases emerging daily. This surge highlights the urgent need for effective treatments, and we’re committed to advancing solutions that restore these essential senses and enhance quality of life for those impacted.
Our FLAVOR Clinical Trial
This Phase 2 FLAVOR trial was designed as a 32-week, randomized, double-blinded, placebo-controlled trial evaluating the safety and effectiveness of CYR-064 as a potential treatment for hyposmia, the partial loss of smell. Topline results indicated the CYR-064 was safe and well-tolerated with durable improvements in smell function across multiple, prespecified, secondary efficacy endpoints
Learn more about olfactory dysfunction
Olfactory dysfunction, or the loss or impairment of the sense of smell, affects millions worldwide. This condition, often caused by viral infections, head trauma, or neurodegenerative diseases, impacts more than just the ability to detect scents; it can significantly affect quality of life, safety, and mental health. People with olfactory dysfunction may struggle with food enjoyment, recognizing hazards like gas leaks or smoke, and even social interactions. Research and treatment advancements, such as those by Cyrano Therapeutics, aim to restore this essential sensory function.
Olfactory System Explained
Smell relies on a delicate pathway: airborne odor molecules reach receptors in the nasal cavity, which send signals through the olfactory nerve to the brain’s smell-processing centers. Because this pathway also connects directly to areas that govern memory and emotion, even small disruptions — from viral infection, injury, or neurodegenerative disease — can affect far more than a person’s ability to detect scent.
Safety & Social Implications
Beyond the loss of enjoyment in food and daily life, impaired smell removes an important safety function: the ability to detect warning signs like smoke, gas leaks, or spoiled food. Studies also link olfactory dysfunction to higher rates of depression and social withdrawal, and in older adults, to increased risk of cognitive decline — underscoring why restoring this sense matters for overall health, not just sensory experience.